Leukemia inhibitory factor and ciliary neurotropic factor promote the survival of Sertoli cells and gonocytes in coculture system.

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the interaction between sertoli cells and luekemia inhibitory factor on the propagation and differentiation of spermatogonial stem cells in vitro

background: sertoli cells play a pivotal role in creating microenvironments essential for spermatogonial stem cells (sscs) self-renewal and commitment to differentiation. maintenance of sscs and or induction of in vitro spermiogenesis may provide a therapeutic strategy to treat male infertility. objective: this study investigated the role of luekemia inhibitory factor (lif) on the propagation o...

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Background: Leptin has been implicated in the differentiation and proliferation of hematopoietic cells. Leukemia inhibitory factor (LIF) may play an important role, along with Interleukin-6 (IL-6) and granulocyte colony stimulating factor (G- CSF), in the regulation of early hematopoietic stem cells. The aim of the study was to evaluate serum level of leptin, LIF, and IL-6 in myeloid leukemia p...

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ژورنال

عنوان ژورنال: Endocrinology

سال: 1996

ISSN: 0013-7227,1945-7170

DOI: 10.1210/endo.137.5.8612528